Current management of severe acquired aplastic anemia

Current management of severe acquired aplastic anemia Tratamento atual da anemia aplástica adquirida grave

Overall survival in severe aplastic anemia has markedly improved in the past four decades due to advances in stem cell transplantation, immunosuppressive therapies and supportive care. Horse anti-thymocyte globulin plus cyclosporine is the standard immunosuppressive regimen in severe aplastic anemia, and often employed as initial therapy as most are not candidates for a matched related stem cel...

The treatment of severe acquired aplastic anemia.

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Acquired severe aplastic anemia: progress and perplexity.

T HE PATHOPHYSIOLOGY and treatment of acquired severe aplastic anemia (ASAA) has been the subject of recent reviews.’2 Whether idiopathic or idiosyncratic, ASAA is a “likely-to-be-fatal” disease.3 However, it has long been recognized that some patients will recover spontaneously, and a few lucky ones may do so with surprisingly rapid restoration of hematopoiesis.35 The inherent unpredictability...

Acquired aplastic anemia.

In aplastic anemia, hematopoiesis fails: Blood cell counts are extremely low, and the bone marrow appears empty. The pathophysiology of aplastic anemia is now believed to be immune-mediated, with active destruction of blood-forming cells by lymphocytes. The aberrant immune response may be triggered by environmental exposures, such as to chemicals and drugs or viral infections and, perhaps, endo...

Aplastic Anemia - Diagnos tics and Therapy of Acquired Aplastic Anemia